Niacin Or B3
Niacin Vitamin is of two forms.
1. Nicotinic Acid
2. Nicotinamide (Niacin Amide)
In body both vitamins perform functions those are related to niacin or vitamin b3. There are also 2 coenzyme forms of niacin those are Nicotinamide adenine dinucleotide and Nicotinamide dinucleotide phosphate. These two coenzymes undergo oxidation reduction reactions by loss or addition of an electron and hydrogen (red).
NAD participates in catabolic reactions and acting as an electron and hydrogen acceptor in glycolysis and in TCA cycle. Under aerobic condition, the reduced NADH is used in converting pyruvate to lactate, so it regenerates NAD. These coenzymes are very important in biochemical reaction pathways of fatty acids synthesis. Cells that synthesize a lot of fatty acids contain highest concentration of NADPH. Then cells those are not undergoing in fatty acid synthesis.
Niacin side effects can be in the case if niacin is in the excessive quantity in body and causing toxicity. Niacin side effects are:
1. Flushing Of Skin (Niacin Flush)
2. Itching
3. Nausea
4. Liver Damage.
Side effects of niacin megadoses are explained below. There is skin flushing (niacin flush) also called dermatitis pigmentation and results into thickness of skin. Skin looks like as sun burns. The first symptoms of flushing niacin are sun burn like scars on the back of hand skin. Skin flushing niacin sided effects is much worse the more it is exposed to sunlight. The patient must be monitored and cured under medical conditions.
Niacin mostly found in following food contents:
1. Mushrooms.
2. Bran.
3. Chicken, Salmon, Beef.
4. Liver.
5. Peanuts And Enriched Grains.
6. Enriched White Bread.
Niacin helps with marijuana and marijuana intake cause many severe effects on health. Intake of niacin helps with marijuana problems and it can resume the toxicity induced by marijuana.
Vitamin b3 is very important and deficiency of vitamin b3 might lead to pellagra. This disease can cause skin, digestive and nervous system disorders. All the skin is like sun burned of severe kind. Pellagra is very cruel disease and it can kill the person as well. This is also characterized as dermatitis pigmentation.
Along with other reactions such as flushing to niacin there are some other as well for example type 1 diabetes in high risk children, as it my lessen autoimmune destruction of beta cells of pancreas. There is also another skin burning effect called rosecea niacin side effects. In it there are scars and pigmentation caused on skin that make it swollen and painful. Rosacea can also be observed in vitamin b2 case.
There is also medically important factor of vitamin b3 that is vitamin b3 reduce high cholesterol level. It cures cholesterol level and megadoses niacin is given to patient. Effect of niacin megadoses is mainly to reduce cholesterol level. Niacin and cholesterol are closely related and with administration of niacin cholesterol can be reduced to very low levels. This is very beneficial for health of patient those are suffering from heart pain because of high cholesterol rate. But sometime these intake as megadoses can be dangerous. If a patient is given megadoses of niacin then he should be monitored and his urine should be examined to see if there is any side effect of niacin overdose is developing. Niacin is rich vitamin that can make you feel healthy after daily intake in diet or taken as supplement foods. Its other uses are very much interesting and it attracts customer to be taken away with him or her for use. Vitamin b3 is playing best role for heart patient and increasing heart problem trend.
Niacin is basically of great importance due to its being an important part of glycolysis. Niacin status can be determined by measuring the amount of its breakdown product, N-methyl Nicotinamide (niaciamide), in the urine. Low amounts suggest deficient status. Niacin high can also be examined by same method.